Bioprocess archivos - Vigenius Biotech

UPSTREAM

pgianferro — Wed, 08 Aug 2018 06:30:13 +0000

Bioreactors, Mixers, Bags & Filters

Optimized solutions for cell culture expansion and fermentation, ensuring efficiency and scalability in upstream bioprocessing.

BIOREACTORS

Design Your Bioreactor to Fit Your Process

At Vigenius Biotech, we partner with ABEC to deliver custom-engineered bioreactors and fermenters tailored to your bioprocess needs. Don’t adapt your upstream process to a standard bioreactor—let your bioreactor be designed for your process. As official representatives of ABEC, we offer both single-use and stainless steel bioreactors and fermenters, ensuring full compliance with your process specifications.

Why ABEC?

With over 45 years of experience, ABEC specializes in customized process solutions for the development and manufacturing of biopharmaceutical products, including:

Vaccines
Monoclonal antibodies
Recombinant proteins
Gene therapy

How Vigenius Supports You

Comprehensive bioprocess services, including equipment maintenance, troubleshooting, and genuine ABEC spare parts.
Accelerated design and construction of bioreactors and fermenters.
Custom-designed single-use biocontainers with the best lead times on the market.

Want to learn more? Contact us at info@vigenius.com

MIXERS

High-Performance Magnetic Mixing Solutions for Bioprocessing

Efficient and precise mixing is a critical step in bioprocessing, ensuring homogeneous distribution of components in buffer solutions, culture media, and pharmaceutical formulations. Magnetic mixing technology has revolutionized upstream processing, offering a sterile, efficient, and scalable solution for liquid-liquid and powder-liquid blending.

Lepure Biotech – Innovation in Single-Use Mixing

Lepure Biotech is a leading provider of single-use bioprocessing solutions, specializing in high-performance magnetic mixing systems. With a strong focus on scalability, sterility, and process efficiency, Lepure Biotech delivers cutting-edge mixing technologies designed to streamline operations, eliminate cleaning requirements, and ensure regulatory compliance in pharmaceutical manufacturing.

LeMagmixer IT – Single-Use Magnetic Mixing System

The LeMagmixer IT is a modular, single-use magnetic mixing system designed for the precise and efficient blending of process liquids. It eliminates the need for cleaning and sterilization, reducing production downtime and validation costs. Equipped with a powerful magnetic drive and servo motor, it provides consistent and high-torque mixing, ensuring homogeneous formulations.

Key Features:

Modular design with customizable hardware and software
Integrated pH measurement, conductivity monitoring, and temperature control
Compatible with MES and SCADA for centralized process control
Hidden cabling for easier cleaning and contamination control
Advanced data management system ensuring traceability and compliance

Applications:

Buffer and media preparation
Mixing of intermediates and vaccine adjuvants
Virus inactivation and semi-finished product formulation

LeMagmixer SP – Scalable Magnetic Mixing System

The LeMagmixer SP offers a highly integrated and scalable magnetic mixing solution, featuring a Siemens-based control system for precise monitoring and automation. With its customizable tank configurations, it allows for flexible adaptation to different biomanufacturing processes, making it ideal for both batch and continuous operations.

Key Features:

Integrated Siemens PLC and WinCC software for seamless process control
Touchscreen interface with real-time data collection and partitioning
Ability to drive two mixing systems simultaneously
Pre-sterilized single-use mixing bags, eliminating cleaning requirements
Shaft-seal-free mixing design, reducing contamination risks

Applications:

Preparation of culture media, buffers, and vaccine adjuvants
Ultrafiltration and ADC purification
High-performance powder-liquid and liquid-liquid mixing

How Vigenius Biotech Supports Your Bioprocess Needs

As the official distributor and partner of Lepure Biotech in the LATAM region, Vigenius Biotech provides expert guidance and technical support for the selection, implementation, and optimization of single-use magnetic mixing systems. Our team ensures:

Seamless integration of Lepure Biotech’s solutions into your production process
Regulatory compliance and GMP validation support
After-sales service, maintenance, and spare parts availability

Want to learn more? Contact us at info@vigenius.com

BAGS

LeKrius Single-Use Bags – Optimized Mixing for Bioprocessing

Single-use bags have become an essential component in modern bioprocessing, offering sterility, flexibility, and efficiency for applications such as media preparation, buffer formulation, and vaccine adjuvant mixing. Designed for scalability and compatibility with magnetic stirring systems, these bags help ensure consistent and reliable mixing performance across different production scales.

Lepure Biotech – Innovation in Single-Use Technologies

With over 10 years of expertise in single-use bioprocessing solutions, Lepure Biotech has developed the LeKrius Single-Use Bag series, featuring a proprietary LeKrius multi-layer coextruded film. These bags provide high-performance mixing capabilities, enabling efficient solid-liquid and liquid-liquid processing while maintaining sterility and process integrity.

LeKrius Single-Use Mixing Bags – Scalable & Customizable Solutions

The LeKrius Mixing Bags are designed to facilitate optimal mixing effects in various bioprocess applications. With five standard bag types and three configuration versions, they offer unparalleled flexibility, allowing biomanufacturers to tailor mixing parameters to their specific needs. Covering everything from research and development to full-scale commercial production, these bags ensure a stable and reproducible mixing process.

Key Features:

Magnetically coupled drive for efficient mixing of powders and suspended particles
Transparent membrane for improved process visibility and monitoring
Flexible customization of size, tubing, connectors, and filters to fit diverse applications
Scalable volumes, ranging from 500 mL to 3000 L, ensuring consistency across batch sizes

Applications:

Preparation of media and buffer solutions
Mixing of vaccine adjuvants
Homogenization of suspended particles and powders

How Vigenius Supports You

As the official distributor and partner of Lepure Biotech in the LATAM region, Vigenius Biotech provides expert consultation, technical support, and tailored solutions for integrating LeKrius Single-Use Bags into your upstream bioprocessing operations.

Custom configuration options to meet specific process requirements
Technical support and troubleshooting for seamless integration
Regulatory compliance and validation assistance
After-sales service and spare parts availability

Want to learn more? Contact us at info@vigenius.com

FILTERS

LeSiever Filters – Reliable Filtration for Bioprocessing

Filtration is a critical step in biopharmaceutical and bioprocessing applications, ensuring product purity, process efficiency, and regulatory compliance. Advanced filtration technologies help remove particles, microorganisms, and contaminants, maintaining the highest quality standards in cell culture media, protein purification, and pharmaceutical production.

Lepure Biotech – Advancing Filtration Technology

Lepure Biotech specializes in high-performance filtration solutions, offering LeSiever filters designed to meet the stringent demands of the biopharmaceutical and bioprocessing industries. These filters provide consistent retention efficiency, ensuring the safety and integrity of critical fluids.

LeSiever Filters – High-Efficiency Filtration for Biomanufacturing

LeSiever filters are designed to provide effective particle and microorganism retention, offering reliable performance in various bioprocessing applications. Manufactured with pharmaceutical-grade materials, they ensure compatibility with sensitive biological products while complying with cGMP and international quality standards.

Key Features:

High filtration efficiency with effective retention of particles and microorganisms
Pharmaceutical-grade materials ensuring compatibility with sensitive bioproducts
Compliance with cGMP standards and international certifications
Available in a wide range of sizes and configurations to suit different processes
Easy integration with standard bioprocessing systems

Applications:

Filtration of cell culture media and buffer solutions
Clarification of proteins and biopharmaceutical products
Purification and separation processes
Removal of particles and biocontaminants in critical fluids

How Vigenius Biotech Supports Your Filtration Needs

As the official distributor of Lepure Biotech in the LATAM region, Vigenius Biotech provides expert support in selecting and implementing LeSiever filtration solutions.
- Consultation on optimal filter configurations for specific processes
- Technical support and troubleshooting
- Regulatory compliance guidance
- After-sales service and spare parts availability
Want to learn more? Contact us at info@vigenius.com

CONTACT US

Need cutting-edge equipment, tailored solutions, or expert consulting? Our team is ready to help. Schedule a consultation today!

Vigenius Biotech is committed to providing top-tier bioprocessing solutions tailored to the needs of biotech companies in the region. Our team offers expert consulting, cutting-edge equipment, and personalized support to help your organization achieve scalability and efficiency in biomanufacturing.

Get in Touch:

Email: info@vigeniusbiotech.com
Phone: +1 (754) 248-7907

Let’s work together to drive innovation and optimize your bioprocesses!

La entrada UPSTREAM se publicó primero en Vigenius Biotech.

DOWNSTREAM

pgianferro — Wed, 08 Aug 2018 06:29:12 +0000

Chromatographs, Resins & Columns

Advanced purification technologies to ensure high-yield protein recovery and compliance with regulatory standards.

CROMATOGRAPHS

High-Performance Chromatographs by Lisure

Reliable and precise chromatography systems for efficient biomolecule separation

APPS Process Chromatography System – Scalable & Automated Separation

Process chromatography is essential for large-scale purification of biological products, ensuring high efficiency and regulatory compliance. Automated chromatography systems streamline equilibration, sample injection, washing, elution, and regeneration, reducing manual intervention and enhancing process consistency.

Lisure – Advanced Solutions for Process Chromatography

Lisure specializes in innovative chromatography technologies for biopharmaceutical manufacturing. Their APPS Process chromatography system is designed for hygienic, automated, and scalable separation, ensuring compliance with ASME BPE and cGMP standards. With a modular and customizable design, it adapts to various production-scale purification processes.

APPS Process Chromatography System – Automated & Scalable Purification

Key Features:

Multiple control platforms available, including Emerson DeltaV, Siemens WinCC, and CBS software, all compliant with FDA 21 CFR Part 11
Hygienic design following ASME BPE and cGMP requirements
User-friendly interface for simple and stable operation
Customizable configurations to meet specific process needs
Flow rate range from 3 L/H to 16,000 L/H, covering diverse production scales
High accuracy with a 1% flow rate precision
Integrated UV, pH, and conductivity detection for precise process monitoring

Applications:

Purification of monoclonal antibodies, recombinant proteins, and vaccines
Separation of biopharmaceutical intermediates
Downstream processing in commercial-scale biomanufacturing

How Vigenius Biotech Supports Your Chromatography Needs

As the official distributor of Lisure in the LATAM region, Vigenius Biotech provides expert guidance, implementation support, and after-sales service for APPS Process chromatography systems.

Assistance in system selection and customization
Regulatory compliance support for cGMP and ASME BPE
Technical support and process optimization
Maintenance services and spare parts availability

Want to learn more? Contact us at info@vigenius.com

RESINS

Tosoh Resins – Optimized Purification for Biopharmaceuticals

High-performance chromatography resins for superior protein purification and recovery

Tosoh’s TOYOPEARL® and TSKgel® resins are industry-leading solutions for high-yield protein purification in bioprocessing. Engineered for high binding capacity, robust stability, and scalability, Tosoh resins enhance downstream purification processes, ensuring optimal performance in affinity, ion exchange, and hydrophobic interaction chromatography. These resins are trusted by biomanufacturers for monoclonal antibody purification, recombinant protein production, and plasma fractionation.

TOYOPEARL Super A – High-Capacity Affinity Resin for mAbs Purification

TOYOPEARL Super A is a next-generation Protein A affinity resin designed for the high-efficiency purification of monoclonal antibodies (mAbs). It offers superior binding capacity, enhanced alkaline stability, and an optimized elution profile, ensuring maximum mAb recovery with minimal elution volume.

Key Features:

High dynamic binding capacity for efficient antibody purification
Superior alkaline stability for extended resin lifetime
Optimized elution conditions for minimal ligand leakage
Ideal for high-titer mAb production with improved ligand durability
Enhances process economy by reducing ligand degradation and maximizing resin lifespan

Applications:

Purification of monoclonal antibodies (mAbs)
Biopharmaceutical manufacturing of high-yield therapeutic proteins
Scalable for clinical and commercial production

How Vigenius Biotech Supports Your Chromatography Needs

As the official distributor of Tosoh in the LATAM region, Vigenius Biotech offers expert consultation, technical support, and after-sales service for TOYOPEARL resins. Our team ensures:

Guidance on selecting the optimal resin for your purification process
Technical support for process optimization and scalability
Regulatory compliance assistance for cGMP manufacturing
Availability of Tosoh resins for large-scale production

Want to learn more? Contact us at info@vigenius.com

COLUMNS

Axial Compression Chromatography Columns – Precision & Scalability

Robust and scalable chromatography columns for high-purity bioprocessing

Chromatography columns are essential for high-efficiency biomolecule separation, ensuring reproducible and consistent purification processes in biopharmaceutical manufacturing. Lisure’s axial compression columns are designed for cGMP production, offering hygienic, user-friendly, and scalable solutions for downstream processing.

Lisure – Advanced Chromatography Column Technology

Robust and scalable chromatography columns for high-purity bioprocessing

Lisure specializes in high-performance chromatography systems, providing customizable and automated solutions for purification processes. Their electrical motor-driven axial compression columns offer enhanced flow distribution, easy maintenance, and compliance with FDA/USP Class VI standards, ensuring efficiency and reliability in large-scale biomanufacturing.

Axial Compression Columns – Optimized for Bioprocessing

Lisure’s axial compression columns are engineered for high-precision packing, reproducible results, and seamless operation. Their patented distribution plate design ensures even flow distribution, enhancing separation efficiency and product recovery.

Key Features:

Hygienic CIP-compatible design, meeting FDA/USP Class VI standards
Patented distributor plate ensuring uniform flow distribution
Transparent acrylic column tube with a rotatable design for easy cleaning and maintenance
Motorized axial compression system for precise and reproducible packing
Customizable configurations to fit various process requirements
IQ/OQ documentation support for validation and regulatory compliance

Applications:

Purification of monoclonal antibodies, recombinant proteins, and viral vectors
Large-scale downstream processing in commercial biomanufacturing
Process development and optimization for high-purity biomolecule separation

How Vigenius Biotech Supports Your Bioprocess Needs

As the official distributor of Lisure in the LATAM region, Vigenius Biotech provides expert guidance, implementation support, and after-sales service for axial compression chromatography columns.

Assistance in system selection and customization
Regulatory compliance support for cGMP production
Technical support and troubleshooting
Maintenance services and spare parts availability

CONTACT US

Need cutting-edge equipment, tailored solutions, or expert consulting? Our team is ready to help. Schedule a consultation today!

Get in Touch:

Email: info@vigeniusbiotech.com
Phone: +1 (754) 248-7907

Let’s work together to drive innovation and optimize your bioprocesses!

La entrada DOWNSTREAM se publicó primero en Vigenius Biotech.

SUPPORT EQUIPMENT

pgianferro — Fri, 29 Jun 2018 10:05:45 +0000

Tube Sealers, Filter Integrity Testers & Cell Disruptors

Essential bioprocess support equipment for maintaining sterility, quality, and process efficiency.

TUBE SEALERS

LePurseal Automatic Aseptic Sealer – Secure & Reliable Tube Sealing

Reliable and sterile sealing solutions for single-use bioprocess applications

Tube sealing is essential for maintaining aseptic conditions in bioprocessing, ensuring sterility and containment in fluid transfer systems. LePurseal’s Automatic Aseptic Sealer II provides a flexible and efficient heat-sealing solution, allowing for the disconnection of thermoplastic tubes while preserving closed-system integrity in non-sterile environments.

Lepure Biotech – Innovation in Aseptic Sealing

Reliable and sterile sealing solutions for single-use bioprocess applications

Lepure Biotech specializes in advanced single-use technologies, offering high-performance aseptic sealing solutions for the biopharmaceutical industry. The LePurseal Automatic Aseptic Sealer II enhances process safety and compliance, supporting sterile fluid management in critical applications such as monoclonal antibodies, vaccines, and cell & gene therapy production.

LePurseal Automatic Aseptic Sealer II – Flexible & Secure Sealing

The LePurseal Automatic Aseptic Sealer II is a versatile and user-friendly sealing system designed for TPE and thermoplastic pump tubes. Its optimized operation system improves efficiency, traceability, and compliance, making it an ideal solution for sterile disconnection in biomanufacturing.

Key Features:

Compatible with tube diameters from 1/4” to 1”, sealing dry, wet, or liquid-filled tubing
Pre-configured settings for commonly used tubing brands, ready for immediate use
Built-in 32GB memory for secure data storage and audit tracking
One-click login and unique account identification for enhanced traceability
Pre-positioning function to minimize incorrect tubing placement
Lightweight and portable for easy integration across different production areas

Applications:

Aseptic disconnection in monoclonal antibody production
Vaccine manufacturing and sterile fluid management
Cell and gene therapy bioprocesses
Integration into single-use bioprocessing workflows

How Vigenius Biotech Supports Your Bioprocess Needs

As the official distributor of Lepure Biotech in the LATAM region, Vigenius Biotech provides expert guidance, technical support, and after-sales service for LePurseal aseptic sealing solutions.

Assistance in system selection and process integration
Regulatory compliance support for aseptic fluid handling
Technical support and troubleshooting
Maintenance services and spare parts availability

Want to learn more? Contact us at info@vigenius.com

FILTER INTEGRITY TESTERS

Lesiever – High-Precision Filter Integrity Testing by Lepure Biotech

Ensuring filtration performance with advanced integrity testing solutions

Ensuring filtration integrity is critical in biopharmaceutical manufacturing, guaranteeing sterility, regulatory compliance, and process reliability. Advanced integrity testing solutions, such as the GS-842, provide automated, accurate, and reproducible testing for sterilizing filters, virus removal filters, and ultrafiltration membranes.

Lepure Biotech – Innovation in Filtration Integrity Testing

Lepure Biotech specializes in cutting-edge filtration solutions, developing advanced integrity testers to meet the highest industry standards. The GS-842 Filter Integrity Tester is the latest generation of a fully automated, high-precision testing platform, designed to enhance efficiency, data security, and compliance with GMP and ALCOA principles.

GS-842 Filter Integrity Tester – Automated & Reliable Performance

The GS-842 Filter Integrity Tester is a full-featured testing system designed for liquid and gas filtration integrity verification. Equipped with real-time data analysis, automatic airflow regulation, and secure audit tracking, it offers fast and precise testing while ensuring compliance with industry regulations.

Key Features:

Comprehensive testing methods, including bubble point, diffusion flow, pressure decay, and water intrusion
Real-time data display and analysis, improving filtration performance monitoring
Advanced algorithms reducing testing time by 20-30% while maintaining accuracy
Secure data management with USB, SD card, and Ethernet connectivity
Four-level authorization management ensuring database security and GMP compliance
Permanent test result storage, allowing for traceable and verifiable audit trails

Applications:

Integrity testing of liquid and gas sterilizing filters
Verification of ultrafiltration membrane packs and hollow fiber membrane columns
Integrity testing of virus removal filters
Pressure integrity testing of stainless steel filtration systems

How Vigenius Biotech Supports Your Filtration Needs

As the official distributor of Lepure Biotech in the LATAM region, Vigenius Biotech provides expert guidance, implementation support, and after-sales service for the GS-842 Filter Integrity Tester.

Selection and customization of filtration integrity testing systems
Regulatory compliance and GMP validation support
Technical assistance and troubleshooting
Maintenance services and spare parts availability

Want to learn more? Contact us at info@vigenius.com

CELL DISRUPTORS

Continuous Flow Cell Disruptors – Precision & Scalability in Cell Lysis

Precision cell disruption for high-yield protein extraction

Cell disruption is a critical step in bioprocessing, ensuring efficient extraction of intracellular components for research and industrial applications. Constant Systems’ CF series of Continuous Flow Cell Disruptors provide high-pressure, precise, and reproducible lysis, making them ideal for bacteria, yeast, algae, and other sample types.

Constant Systems’ HFR, CF1, and CF2 cell disruptors deliver high-pressure homogenization for efficient and reproducible cell lysis. These systems maximize protein recovery while maintaining product integrity, making them ideal for recombinant protein production, microbial fermentation, and vaccine development. Designed for scalability and precision, Constant Systems’ disruptors offer automated pressure control, minimal heat generation, and consistent performance, ensuring superior downstream processing for biopharmaceutical applications.

Constant Systems – Advanced Cell Disruption Technology

Constant Systems specializes in high-performance cell disruption solutions, offering scalable and fully controlled hydraulic systems that ensure consistent processing across all volumes. The CF1 and CF2 models provide continuous-flow processing with precise pressure control, eliminating the need for multiple passes and improving sample integrity and reproducibility.

CF1 Model – Compact & Versatile for Small-Scale Processing

The CF1 Cell Disruptor is a bench-mountable or trolley-mounted unit, ideal for processing volumes between 15mL and 10L. With a maximum pressure of 40 kpsi (2700 bar), it ensures high-efficiency lysis in a single pass, eliminating the need for multiple processing cycles. The CF1 can be equipped with an integrated peristaltic pump, maintaining continuous sample flow and preventing sedimentation during processing.

Key Features:

Compact footprint (700mm²), adaptable for bench or trolley mounting
Processing speed up to 6L per hour, making it ideal for small-to-medium-scale applications
Integrated peristaltic pump (optional) for continuous feeding and recirculation
Compatible with fluid, re-suspended, viscous, and frozen samples
Digitally controlled pressure adjustment, ensuring repeatable and precise results

Applications:

Bacterial, yeast, and algae cell lysis
Protein extraction for biopharmaceutical research and production
Sample preparation for biotechnology and life sciences

CF2 Model – Scalable Solution for High-Volume Processing

The CF2 Cell Disruptor is a floor-standing unit, designed for larger-scale cell disruption, handling volumes from 15mL to 100L. It features an integrated peristaltic pump as standard, ensuring a continuous and uniform flow of samples. The high-pressure hydraulic control guarantees that 99% of the sample is processed at the set pressure, ensuring reproducibility and efficiency.

Key Features:

Floor-standing model with a stable, compact footprint (700mm²)
Processing speed up to 24L per hour, ideal for large-scale bioprocessing
Integrated peristaltic pump for continuous flow and sample homogeneity
No need for compressed air or gas, operates on standard electrical supply
Industry-standard cleaning compatibility, allowing easy cleaning and sterilization

Applications:

Large-scale bacterial and yeast cell lysis
Protein and nucleic acid extraction for industrial biomanufacturing
High-throughput biotechnology and pharmaceutical applications

How Vigenius Biotech Supports Your Cell Disruption Needs

As the official distributor of Constant Systems in the LATAM region, Vigenius Biotech provides expert consultation, implementation support, and after-sales service for CF series cell disruptors.

Assistance in selecting the right model based on process scale and application
Regulatory compliance support for biopharmaceutical production
Technical support and troubleshooting
Maintenance services and spare parts availability

CONTACT US

Need cutting-edge equipment, tailored solutions, or expert consulting? Our team is ready to help. Schedule a consultation today!

Get in Touch:

Email: info@vigeniusbiotech.com
Phone: +1 (754) 248-7907

Let’s work together to drive innovation and optimize your bioprocesses!

La entrada SUPPORT EQUIPMENT se publicó primero en Vigenius Biotech.